Publications — P.S.K Biosciences

Peer-Reviewed Research

Selected Publications

Our research is published in leading scientific journals and validated by the global scientific community.

Journal of Extracellular Vesicles

Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography

Wei Liu, Xinyu Wang, Yating Chen, Jiapei Yuan, Huiyu Zhang, Xin Jin, Yuying Jiang, Junjing Cao, Zibin Wang, Shuo Yang, Bingwei Wang, Tinghe Wu, Jing Li

This study establishes a protocol for large-scale production of MSC-derived sEV subpopulations from human umbilical cord MSCs using TFF combined with SEC. The resulting S1-sEVs (CD9/HRS/GPC1 enriched) showed greater immunomodulatory impact, while S2-sEVs (CD63/FLOT1/2 enriched) showed enhanced capacities in promoting cell proliferation and angiogenesis—demonstrating distinct functions both in vitro and in animal disease models.

DOI: 10.1002/jev2.70029 · Published 2024

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ICNS 2026 · Conference Presentation

Presentation at ICNS 2026

P.S.K Biosciences

This ICNS 2026 presentation summarizes the competitive landscape of CNS and extrahepatic RNA delivery and highlights the shift from tissue exposure to productive intracellular biology. It introduces P.S.K Biosciences’ SGRL-Exo™ platform as a structure-guided, biologically manufactured exosome system designed for systemic, functional CNS RNA delivery, supported by early evidence in RNA loading, brain exposure, cellular uptake, multi-region knockdown, and CMC consistency.